about life—the thing that drives me absolutely crazy—is the degree to which you can know virtually nothing at all for certain, and (in something of a corollary), the almost utter lack of control over your own life that this implies.
Most of all, it is other people that absolutely drive me insane. One needs them, desperately, in general. There is also no way ever, in any way, to know for sure what they are thinking, what they might do at any particular moment or in response to any particular stimulus. You are utterly at their mercy, whether with them (and thus subject to their intentions) or without them (and thus needing them almost to the point of incapacity).